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Matrix Gla protein MGP is a calcification inhibitor in vascular tissue that must be carboxylated by vitamin K to function. Evidence suggests circulating uncarboxylated MGP ucMGP is elevated in persons with disease characterized by vascular calcification. The primary purpose of this study was to determine cross-sectional and longitudinal associations between plasma ucMGP, vitamin K status, and coronary artery calcium CAC in older adults without coronary heart disease. Genetic determinants of ucMGP were also explored. Major allele homozygotes for MGP rs and rs had higher plasma ucMGP than heterozygotes or minor allele homozygotes.
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